STING agonist-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

STING agonist-1 是一种人类特异性 STING 激动剂，可引发针对新兴甲病毒的抗病毒活性。

STING agonist-1 is a human-specific STING agonistelicits antiviral activity against emerging Alphaviruses.?

G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts.G10 is an indirect activator of human STING-dependent phenotypes.G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling.STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity.G10 induces STING-dependent synthesis and secretion of bioactive interferon.G10 induces innate antiviral mRNA expression in primary human cells.

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G10

Immunology/Inflammation

STING

STING

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702662-50-8

430.88

C21H16ClFN2O3S

>98% (HPLC)

DMSO:100 mg/mL (232.08 mM; Need ultrasonic)

Fc1cccc(Cl)c1CN1C(=O)CSc2ccc(cc12)C(=O)NCc1ccco1

4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-34-dihydro-2H-benzo[b][14]thiazine-6-carboxamide

(-20℃)

With Ice Pack

≥ 2 years